Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation
MT Savino, B Ortensi, M Ferro, C Ulivieri… - The Journal of …, 2009 - journals.aai.org
Rai (ShcC) belongs to the family of Shc adaptor proteins and is expressed in neuronal cells,
where it acts as a survival factor activating the PI3K/Akt survival pathway. In vivo, Rai
protects the brain from ischemic damage. In this study, we show that Rai is expressed in T
and B lymphocytes. Based on the finding that Rai−/− mice consistently develop
splenomegaly, the role of Rai in lymphocyte homeostasis and proliferation was addressed.
Surprisingly, as opposed to neurons, Rai was found to impair lymphocyte survival …
where it acts as a survival factor activating the PI3K/Akt survival pathway. In vivo, Rai
protects the brain from ischemic damage. In this study, we show that Rai is expressed in T
and B lymphocytes. Based on the finding that Rai−/− mice consistently develop
splenomegaly, the role of Rai in lymphocyte homeostasis and proliferation was addressed.
Surprisingly, as opposed to neurons, Rai was found to impair lymphocyte survival …
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